In all eukaryotes, including plants, genomic DNA is packaged around octamers of histones, forming the basic structural units of chromatin, the nucleosomes. Chromatin represents the physiological template of genetic information. Epigenetics refer to heritable changes (during mitosis and sometimes meiosis) of genome function that occur without a change in DNA sequence. Well-known epigenetic mechanisms include ATP-dependent chromatin remodeling, nucleosome assembly/disassembly, histone variant incorporation, covalent modifications of histones (e.g. acetylation, methylation and ubiquitylation) and DNA (e.g. methylation). Regulatory factors involved in these epigenetic mechanisms play crucial roles in many aspects of plant growth and development, including flowering time control, seed development, cell fate maintenance and plant responses to environmental factors. Our group is interested in characterization of several genes to reveal their roles in deposition of epigenetic marks, in chromatin remodeling, in genome transcription, and in regulation of plant growth and development.
To be, or not to be, remethylated
Nature Plants, 6:606-607, 2020. | DOI : 10.1038/s41477-020-0696-1
ZHAO W., NEYT P., VAN LIJSEBETTENS M., SHEN W.H. and BERR A.
Interactive and non-interactive roles of histone H2B monoubiquitination and H3K36 methylation in the regulation of active gene transcription and control of plant growth and development
New Phytologist, 221:1101-1116, 2019. | DOI : 10.1111/nph.15418
LIU B., LIU Y., WANG B., LUO Q., SHI J., GAN J., SHEN W.H., YU Y. and DONG A.
The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment
Nature Communications, 10:2999, 2019. | DOI : 10.1038/s41467-019-10850-5
GRAINDORGE S., COGNAT V., JOHANN TO BERENS P., MUTTERER J. and MOLINIER J.
Photodamage repair pathways contribute to the accurate maintenance of the DNA methylome landscape upon UV exposure
PLoS Genetics, 15(11):e1008476, 2019. | DOI : 10.1371/journal.pgen.1008476
JIANG L., LI D., JIN L., RUAN Y., SHEN W.H. and LIU C.
Histone lysine methyltransferases BnaSDG8.A and BnaSDG8.C are involved in the floral transition in Brassica napus
Plant Journal, 95:672-685, 2018. | DOI : 10.1111/tpj.13978