Epigenetic mechanisms in signaling of plant development

Group leader : Wen Hui SHEN

Research area

In all eukaryotes, including plants, genomic DNA is packaged around octamers of histones, forming the basic structural units of chromatin, the nucleosomes. Chromatin represents the physiological template of genetic information. Epigenetics refer to heritable changes (during mitosis and sometimes meiosis) of genome function that occur without a change in DNA sequence. Well-known epigenetic mechanisms include ATP-dependent chromatin remodeling, nucleosome assembly/disassembly, histone variant incorporation, covalent modifications of histones (e.g. acetylation, methylation and ubiquitylation) and DNA (e.g. methylation). Regulatory factors involved in these epigenetic mechanisms play crucial roles in many aspects of plant growth and development, including flowering time control, seed development, cell fate maintenance and plant responses to environmental factors. Our group is interested in characterization of several genes to reveal their roles in deposition of epigenetic marks, in chromatin remodeling, in genome transcription, and in regulation of plant growth and development.

Members

Selected publications

  • MOLINIER J.

    To be, or not to be, remethylated

    Nature Plants, 6:606-607, 2020. | DOI : 10.1038/s41477-020-0696-1DOI logo

  • ZHAO W., NEYT P., VAN LIJSEBETTENS M., SHEN W.H. and BERR A.

    Interactive and non-interactive roles of histone H2B monoubiquitination and H3K36 methylation in the regulation of active gene transcription and control of plant growth and development

    New Phytologist, 221:1101-1116, 2019. | DOI : 10.1111/nph.15418DOI logo

  • LIU B., LIU Y., WANG B., LUO Q., SHI J., GAN J., SHEN W.H., YU Y. and DONG A.

    The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment

    Nature Communications, 10:2999, 2019. | DOI : 10.1038/s41467-019-10850-5DOI logo

  • GRAINDORGE S., COGNAT V., JOHANN TO BERENS P., MUTTERER J. and MOLINIER J.

    Photodamage repair pathways contribute to the accurate maintenance of the DNA methylome landscape upon UV exposure

    PLoS Genetics, 15(11):e1008476, 2019. | DOI : 10.1371/journal.pgen.1008476DOI logo

  • JIANG L., LI D., JIN L., RUAN Y., SHEN W.H. and LIU C.

    Histone lysine methyltransferases BnaSDG8.A and BnaSDG8.C are involved in the floral transition in Brassica napus

    Plant Journal, 95:672-685, 2018. | DOI : 10.1111/tpj.13978DOI logo