Plant growth is subject to hormonal control and must adapt to environmental cues (nutrient availability, water supply, light, temperature) or stress. Major developmental growth regulators are the gibberellins (GAs), a family of tetracyclic diterpenoid molecules that play important roles in diverse developmental processes such as seed germination, growth and the induction of flowering. Hence, mutant plants that are deficient in GAs exhibit a dwarf and late flowering phenotype, and treating these plants with GAs restores normal growth. The role of GAs in determining plant stature had major impacts on agriculture in the 1960’s, and the development of semi-dwarf varieties that show altered GA responses contributed to a huge increase in grain yields during the “green revolution”. During the past decade, substantial progress has been made in understanding the GA metabolism, transport and signaling cascade, from GA perception to the activation of transcriptional networks that regulate plant development. Our group is mostly focused on the mechanisms allowing GA-responsive growth under different environmental conditions. We are also investigating the transport of GAs in plants, particularly the long-distance movement of endogenously made GAs across plant organs.
Regulatory mechanisms of GA/DELLA action
The phytohormone GA has long been known to control growth by stimulating the degradation of nuclear growth-repressing DELLA proteins, however the mechanism allowing GA-responsive growth is only slowly emerging. An important function of DELLAs relies on their ability to establish protein-protein interaction with diverse classes of regulatory proteins and transcription factors. By doing so, DELLAs control the expression of a multitude of target genes functioning in distinct pathways. Our goal is to unravel through genetics and cell imaging the specificity, consequence and dynamics of these interactions in planta.