Gene expression regulation is a complex, integrated and extremely plastic process resulting from transcriptional, epigenetic and post-transcriptional regulations. Post-transcriptional regulations can occur at all stages of messenger RNA (mRNA), from their synthesis to their translation.
In the cytoplasm, mRNAs are in a constant balance between translation, storage and degradation. Our team seeks to understand how the regulation of this balance can adjust gene expression during development and in response to abiotic stresses in plants.
We use Arabidopsis thaliana and Solanum lycopersicum as plants models in an integrative experimental biology approach including high-throughput sequencing, molecular biology, biochemistry and genetic approaches.
Our work focuses on two major biological questions : (1) the characterization of cis and trans elements involved in the regulation of mRNA fate and (2) the physiological and cellular contributions of mRNA degradation.
Our research program is currently funded by an ANR MATILDA grant (2021-2025) and an IEA program (International Emerging Actions: UArizona/CNRS).
