Metabolomics

Leader: Hubert SCHALLEREmmanuel GAQUEREL

Description

The platform is specialized in the development of experimental design aimed to the identification of small bioactive molecules coming from plants mainly but also from animals, microbes and human. Small molecules made by living organism are also named metabolites. Therefore has been coined in the late 90s the word Metabolomics which represent the field that study the metabolomes. In our group small molecules identification is made by means of modern analytical tools using chromatography and mass spectrometry.

Expertises

Understanding of plant metabolic networks

Manager : Julie ZUMSTEG

A big challenge for modern agriculture relies on a better understanding of plant metabolic networks responsible of plant growth, plant resistance and plant defense. The project consist on the identification of large set of metabolites, several hundreds of metabolites simultaneously in one single analysis without the need of labeling or purification.

Finding novel Plant derived drugs

Plants contain the largest set of metabolites among the living organism and 80% of the drugs available in modern medicine are plant derived metabolites.

Members

Recent publications

  • RIGO R., ZUMSTEG J., SCHALLER H., BARCHIETTO T., BUCHET S., HEINTZ D. and VILLETTE C.

    BW312 Hordeum vulgare semi ‑ dwarf mutant exhibits a shifted metabolic profile towards pathogen resistance

    Metabolomics, 10, 2024. | DOI : 10.1007/s11306-024-02174-3DOI logo

  • VILLETTE C., MAURER L., ZUMSTEG J., MUTTERER J., WANKO A. and HEINTZ D.

    Mass spectrometry imaging for biosolids characterization to assess ecological or health risks before reuse

    Nature Communications, 4244, 2023. | DOI : https://doi.org/10.1038/s41467-023-40051-0DOI logo

  • ZUMSTEG J., HIRSCHLER A., CARAPITO C., MAURER L., VILLETTE C., HEINTZ D., DAHL C., EL NAYAL A., SANGAL V., MAHMOUD H., VAN DORSSELAER A. and ISMAIL W.

    Mechanistic insights into sulfur source-driven physiological responses and metabolic reorganization in the fuel-biodesulfurizing Rhodococcus qingshengii IGTS8

    Applied and Environmental Microbiology, 89:1, 2023. | DOI : https://doi.org/10.1128/aem.00826-23DOI logo

  • ZUMSTEG J., BOSSARD E., GOURGUILLON L., VILLETTE C. and HEINTZ D.

    Comparison of nocturnal and diurnal metabolomes of rose flowers and leaves

    Metabolomics, 1-12, 2023. | DOI : https://doi.org/10.1007/s11306-023-02063-1DOI logo

  • GRÉAU L., BLAUDEZ D., HEINTZ D., ZUMSTEG J., BILLET D. and CEBRON A.

    Response of Poplar and Associated Fungal Endophytic Communities to a PAH Contamination Gradient

    International Journal of Molecular Sciences, 23:5909, 2022. | DOI : https://doi.org/10.3390/ijms23115909DOI logo