Defined as the powerhouse of the cell, the mitochondrion is also involved in many other vital biological processes. All these processes require an important communication between the mitochondrion and the other cellular compartments. Furthermore, the biogenesis of this organelle is complex and implies the coordinated expression of the nuclear and mitochondrial genomes as the latter one only codes for a limited set of genes.
In this context, studies concerning the metabolism of RNAs and the trafficking of RNAs between mitochondria and the other cellular compartments represent a rapidly growing and still very widely underestimated domain. Presently our main objectives are to deepen our knowledge by answering the following biological questions:
- What are the ways of tRNA cleavage in the plant cell and which are the roles played by the small non coding RNAs generated by these cleavages?
- What is the importance of the mRNA targeting process at the surface of mitochondria and how is the translation of mRNAs associated with organelles organized and regulated within the plant cell?
- What are the cis and trans elements implicated in mitochondrial translation?
This work is done under the framework of the Laboratory of Excellence (LabEx) MitoCross.