Plants are sessile organisms that are continuously exposed to various stresses (mechanical, abiotic and biotic stresses) during their development. They have evolved mechanisms to regulate their growth and adapt to these stresses, through signaling pathways transmitted to the nucleus.We aim at deciphering these pathways using interdisciplinary approaches (-omics, cellular, physics, genetics and (epi)genomics) through the study of key players located at the nucleo-cytoplasmic interface. We are interested in GIP proteins, regulators of both microtubular networks and nuclear architecture, as well as in regulators of genome integrity maintenance in response to UV irradiation.Our research programs are partly funded by international (HFSP, IdEX Unistra) and national (ANR) programmes. Our team is part of an European COST network (INDEPTH- Action 16212).
Role of GIPs and their partners in the mechanical stress response
Project manager: Marie-Edith CHABOUTÉ
GIPs which are present on both sides of the nuclear envelope, likely participate in signal transduction upon abiotic stress. As gip1gip2 mutants exhibit strongly altered nuclear phenotypes, their response to mechanical stimuli may be impaired. We are looking how GIPs are involved in the responses to stress perceived at the nuclear envelope and our goal is to identify the underlying mechanisms.