Nos publications

MOGHE G., KRUSE L., PETERSEN M., SCOSSA F., FERNIE A., GAQUEREL E. and D'AURIA J.

BAHD Company: The Ever-Expanding Roles of the BAHD Acyltransferase Gene Family in Plants

Annual Review of Plant Biology, 74:165-194, 2023. | DOI : doi: 10.1146/annurev-arplant-062922-050122

STITZ M., KUSTER D., REINERT M., SCHEPETILNIKOV M., BERTHET B., REYES-HERNÁNDEZ J., JANOCHA D., ARTINS A., BOIX M., HENRIQUES R., PFEIFFER A., LOHMANN J., GAQUEREL E. and MAIZEL A.

TOR acts as metabolic gatekeeper for auxin-dependent lateral root initiation in Arabidopsis thaliana

EMBO Journal, 42(10):e111273, 2023. | DOI : doi: 10.15252/embj.2022111273.

HU R., LI X., HU Y., ZHANG R., LV Q., ZHANG M., SHENG X., ZHAO F., CHEN Z., DING Y., YUAN H., WU X., XING S., YAN X., BAO F., WAN P., XIAO L., WANG X., XIAO W., DECKER E.L., VAN GESSEL N., RENAULT H., WIEDEMANN G., HORST N.A., HAAS F.B., WILHELMSSON P.K., ULLRICH K.K., NEUMANN E., LV B., LIANG C., DU H., LU H., GAO Q., CHENG Z., YOU H., XIN P., CHU J., HUANG C.H., LIU Y., DONG S., ZHANG L., CHEN F., DENG L., DUAN F., ZHAO W., LI K., LI Z., LI X., CUI H., ZHANG Y.E., MA C., ZHU R., JIA Y., WANG M., HASEBE M., FU J., GOFFINET B., MA H., RENSING S.A., RESKI R. and HE Y.

Adaptive evolution of the enigmatic Takakia now facing climate change in Tibet

Cell, 186(17):3558-3576, 2023. | DOI : 10.1016/j.cell.2023.07.003

ELSER D., PFLIEGER D., VILLETTE C., MOEGLE B., MIESCH L. and GAQUEREL E.

Evolutionary metabolomics of specialized metabolism diversification in the genus Nicotiana highlights N-acylnornicotine innovations

Science Advances, 9(34), 2023. | DOI : 10.1126/sciadv.ade8984

BAI Y., YANG C., HALTISCHKE R., PAETZ C., KESSLER D., BURKARD K., GAQUEREL E., BALDWIN I.T. and LI D.

Natural history-guided omics reveals plant defensive chemistry against leafhopper pests

Science, 375(6580), 2022. | DOI : doi: 10.1126/science.abm2948.

ELSER D., PFLIEGER D., VILLETTE C., MOEGLE B., MIESCH L. and GAQUEREL E.

Evolutionary metabolomics of specialized metabolism diversification in the genus Nicotiana highlights allopolyploidy-mediated innovations in N-acylnornicotine metabolism

Science Advances, , 2022.

FIGON F., BALDWIN I.T. and GAQUEREL E.

Ethylene is a local modulator of jasmonate‐dependent phenolamide accumulation during Manduca sexta herbivory in Nicotiana attenuata

Plant Cell and Environment, , 2021. | DOI : 10.1111/pce.13955

KRIEGSHAUSER L., KNOSP S., GRIENENBERGER E., TATSUMI K., GÜTLE D.D., ZUMSTEG J., RESKI R., ROSE J.K.C., WERCK D. and RENAULT H.

Function of the HYDROXYCINNAMOYL-CoA:SHIKIMATE HYDROXYCINNAMOYL TRANSFERASE is evolutionarily conserved in embryophytes

Plant Cell, 33(5):1472–1491, 2021. | DOI : 10.1093/plcell/koab044

HEILING S., CORTES LLORCA L., LI J., GASE K., SCHMIDT A., SCHÄFER M., SCHNEIDER B., HALITSCHKE R., GAQUEREL E. and BALDWIN I.T.

Specific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata

Plant Cell, , 2021. | DOI : 10.1093/plcell/koab048

LI D. and GAQUEREL E.

Next-Generation Mass Spectrometry Metabolomics Revives the Functional Analysis of Plant Metabolic Diversity

Annual Review of Plant Biology, 72, 2021. | DOI : 10.1146/annurev-arplant-071720-114836

VAN ZADELHOFF A., DE BRUIJN W.J.C., FANG Z., GAQUEREL E., ISHIHARA A., WERCK D., ZHANG P., ZHOU G., FRANSSEN M.C.R. and VINCKEN J.P.

Toward a Systematic Nomenclature for (Neo)Lignanamides

Journal of natural products, -, 2021. | DOI : doi: 10.1021/acs.jnatprod.0c00792

HEITZ T.

Jasmonate Metabolism : Shaping Signals for Plant Stress Adaptation and Development.

In: Joseph Jez (ed) Encyclopedia of Biological Chemistry, vol 2. Elsevier Major Reference Work., 2021. | DOI : 10.1016/B978-0-12-819460-7.00019-0

WOLF E., GAQUEREL E., SCHARMANN M., YANT L. and KOCH M.

Evolutionary footprints of a cold relic in a rapidly warming world

eLife, 10(e71572), 2021. | DOI : 10.7554/eLife.71572

NAAKE T., GAQUEREL E. and FERNIE A.

Annotation of Specialized Metabolites from High-Throughput and High-Resolution Mass Spectrometry Metabolomics

In: Methods in Molecular Biology book series (ed) Computational Methods and Data Analysis for Metabolomics., Humana., 2020. | DOI : 10.1007/978-1-0716-0239-3_12

MARQUIS V., SMIRNOVA E., POIRIER L., ZUMSTEG J., SCHWEIZER F., REYMOND P. and HEITZ T.

Stress- and pathway-specific impacts of impaired jasmonoyl- isoleucine (JA-Ile) catabolism on defense signalling and biotic stress resistance

Plant Cell and Environment, 43:1558-1570, 2020. | DOI : 10.1111/pce.13753

HARDION L., PERRIER A., MARTINEZ M., NAVROT N., GAQUEREL E., TOURNAY F., NGUEFACK J. and COMBROUX I.

Integrative revision of Dianthus superbus subspecies reveals different degrees of differentiation, from plasticity to species distinction

Systematics and Biodiversity, 18(3), 2020. | DOI : 10.1080/14772000.2020.1737979

LI D., HALITSCHKE R., BALDWIN I.T. and GAQUEREL E.

Information theory tests critical predictions of plant defense theory for specialized metabolism

Science Advances, 6(24):eaaz0381, 2020. | DOI : 10.1126/sciadv.aaz0381

VALIM H., DALTON H., JOO Y., MCGALE E., HALITSCHKE R., GAQUEREL E., BALDWIN I.T. and SCHUMAN M.C.

TOC1 in Nicotiana Attenuata Regulates Efficient Allocation of Nitrogen to Defense Metabolites Under Herbivory Stress

New Phytologist, 228(4):1227-1242, 2020. | DOI : 10.1111/nph.16784

WANG D., TABTI R., ELDERWISH S., DJEHAL A., CHOUHA N., PINOT F., YU P., NEBIGIL C.G. and DÉSAUBRY L.

Evolutionarily conserved SFPH proteins as therapeutic targets for a myriad of diseases

Bioorganic & Medicinal Chemistry, 127600, 2020.

SINGH A.P., PANDEY B., MEHRA P., HEITZ T. and GIRI J.

OsJAZ9 overexpression modulates jasmonic acid biosynthesis and potassium deficiency responses in rice

Plant Molecular Biology, 104:397-410, 2020. | DOI : 10.1007/s11103-020-01047-2

ABDOLLAHI F., ALEBRAHIM M.T., NGOV C., LALLEMAND E., ZHENG Y., VILLETTE C., ZUMSTEG J., ANDRE F., NAVROT N., WERCK D. and MIESCH L.

Innate promiscuity of the CYP706 family of P450 enzymes provides a suitable context for the evolution of dinitroaniline resistance in weed

New Phytologist, , 2020. | DOI : 10.1111/nph.17126

TENG L., FAN X., NELSON D., HAN W., ZHANG X., XU D., RENAULT H., MARKOV G. and YE N.

Diversity and evolution of cytochromes P450 in stramenopiles

Planta, 249(3):647–661, 2019. | DOI : 10.1007/s00425-018-3028-1

RENAULT H., WERCK-REICHHART D. and WENG J.K.

Harnessing lignin evolution for biotechnological applications

Current Opinion in Biotechnology, 56:105-111, 2019. | DOI : 10.1016/j.copbio.2018.10.011

ALBER A., RENAULT H., BASILIO LOPES A., BASSARD J.E., LIU Z., ULLMANN P., LESOT A., BIHEL F., SCHMITT M., WERCK-REICHHART D. and EHLTING J.

Evolution of coumaroyl conjugate 3‐hydroxylases in land plants: Lignin biosynthesis and defense

Plant Journal, 99:924-936, 2019. | DOI : 10.1111/tpj.14373

HEITZ T., SMIRNOVA E., MARQUIS V. and POIRIER L.

Metabolic control within the jasmonate biochemical pathway

Plant and Cell Physiology, pcz172, 2019. | DOI : 10.1093/pcp/pcz172

HAZMAN M., SÜHNEL M., SCHÄFER S., ZUMSTEG J., LESOT A., BELTRAN F., MARQUIS V., HERRGOTT L., MIESCH L., RIEMANN M. and HEITZ T.

Characterization of Jasmonoyl-Isoleucine (JA-Ile) Hormonal Catabolic Pathways in Rice upon Wounding and Salt Stress

Rice, 45, 2019. | DOI : 10.1186/s12284-019-0303-0

GALLEGO A., ROJAS L.F., RODRIGUEZ H.A., MORA C., ATEHORTUA L., URREA A.I., GUILTINAN M.J., MAXIMOVA S.N., GAQUEREL E., ZULUAGA M. and PABON-MORA N.

Metabolomic profile of cacao cell suspensions growing in blue light/dark conditions with potential in food biotechnology

Plant Cell, Tissue and Organ Culture, 1-20, 2019. | DOI : https://doi.org/10.1007/s11240-019-01679-

BOACHON B., BURDLOFF Y., RUAN J.X., ROJO R., JUNKER R.R., VINCENT B., NICOLÈ F., BRINGEL F., LESOT A., HENRY L., BASSARD J.E., MATHIEU S., ALLOUCHE L., KAPLAN I., DUDAREVA N., VUILLEUMIER S., MIESCH L., ANDRE F., NAVROT N., CHEN X.Y. and WERCK D.

A Promiscuous CYP706A3 Reduces Terpene Volatile Emission from Arabidopsis Flowers, Affecting Florivores and the Floral Microbiome

Plant Cell, 31(12):2947-2972, 2019. | DOI : 10.1105/tpc.19.00320

ILC T., ARISTA G., TAVARES R., NAVROT N., DUCHENE E., VELT A., CHOULET F., PAUX E., FISCHER M., NELSON D.R., HUGUENEY P., WERCK D. and RUSTENHOLZ C.

Annotation, classification, genomic organization and expression of the Vitis vinifera CYPome

PLoS ONE, e0199902, 2018. | DOI : 10.1371/journal.pone.0199902

SCHUMAN M., MELDAU S., GAQUEREL E., DIEZEL C., MCGALE E., GREENFIELD S. and BALDWIN I.T.

The active jasmonate JA-ILE regulates a specific subset of plant jasmonate-mediated resistance to herbivores in nature

Frontiers in Plant Science, , 2018.

PETERS K., WORRICH A., WEINHOLD A., ALKA O., BALCKE G., BIRKEMEYER C., BRUELHEIDE H., CALF O., DIETZ S., DÜHRKOP K., GAQUEREL E., HEINING U., KÜCKLICH M., MACEL M., MÜLLER C., POESCHL Y., POHNERT G., RISTOK C., RODRÍGUEZ V., RUTTKIES C., SCHUMAN M., SCHWEIGER R., SHAHAF N., STEINBECK C., TORTOSA M., TREUTLER H., UEBERSCHAAR N., VELASCO P., WEISS B., WIDDIG A., NEUMANN S. and VAN DAM N.

Current challenges in plant eco-metabolomics

International Journal of Molecular Sciences, 1385, 2018.

RENAULT H., DE MAROTHY M., JONASSON G., LARA P., NELSON D.R., NILSSON I., ANDRE F., VON HEIJNE G. and WERCK-REICHHART D.

Gene duplication leads to altered membrane topology of a cytochrome P450 enzyme in seed plants

Molecular Biology and Evolution, 34(8):2041-2056, 2017. | DOI : 10.1093/molbev/msx160

RENAULT H., ALBER A., HORST N.A., BASILIO LOPES A., FICH E.A., KRIEGSHAUSER L., WIEDEMANN G., ULLMANN P., HERRGOTT L., ERHARDT M., PINEAU E., EHLTING J., SCHMITT M., ROSE J.K., RESKI R. and WERCK D.

A phenol-enriched cuticle is ancestral to lignin evolution in land plants

Nature Communications, 8:14713, 2017. | DOI : 10.1038/ncomms14713

PINEAU E., XU L., RENAULT H., TROLET A., NAVROT N., ULLMANN P., LÉGERET B., VERDIER G., BEISSON F. and PINOT F.

Arabidopsis thaliana EPOXIDE HYDROLASE1 (AtEH1) is a cytosolic epoxide hydrolase involved in the synthesis of poly-hydroxylated cutin monomers

New Phytologist, 215(1):173-186, 2017. | DOI : 28497532

ILC T., HALTER D., MIESCH L., LAUVOISARD F., KRIEGSHAUSER L., ILG A., BALTENWECK R., HUGUENEY P., WERCK D., DUCHÊNE E. and NAVROT N.

A grapevine cytochrome P450 generates the precursor of wine lactone, a key odorant in wine

New Phytologist, 213(1):264-274, 2017. | DOI : 10.1111/nph.14139

SMIRNOVA E., MARQUIS V., POIRIER L., AUBERT Y., ZUMSTEG J., MENARD R., MIESCH L. and HEITZ T.

Jasmonic Acid Oxidase 2 (JAO2) hydroxylates jasmonic acid and represses basal defense and resistance responses against Botrytis cinerea infection

Molecular Plant, 10(9):1159-1173, 2017. | DOI : 10.1016/j.molp.2017.07.010

XU S., BROCKMÖLLER T., NAVARRO QUEZADA A., KUHL H., GASE K., LING Z., ZHOU W., KREITZER C., STANKE M., TANG H., LYONS E., PANDEY P., PANDEY S.P., TIMMERMANN B., GAQUEREL E. and BALDWIN I.T.

Wild tobacco genomes reveal the evolution of nicotine biosynthesis

Proceedings of the National Academy of Sciences of the United States of America, 114(23):6133-6138, 2017. | DOI : 10.1073/pnas.1700073114

STITZ M. and GAQUEREL E.

Insect Resistance: An Emerging Molecular Framework Linking Plant Age and JA Signaling

Molecular Plant, 10:537-539, 2017. | DOI : 10.1016/j.molp.2017.02.006

LUU V.T., WEINHOLD A., ULLAH C., DRESSEL S., SCHOETTNER M., GASE K., GAQUEREL E. and BALDWIN I.T.

O-acyl sugars protect a wild tobacco from both native fungal pathogens and a specialist herbivore

Plant Physiology, 174:370-386, 2017. | DOI : 10.1104/pp.16.01904

NAAKE T. and GAQUEREL E.

MetCirc: navigating mass spectral similarity in high-resolution MS/MS metabolomics data

Bioinformatics, 2419-2420, 2017. | DOI : doi: 10.1093/bioinformatics/btx159

BROCKMÖLLER T., LING Z., LI D., GAQUEREL E., BALDWIN I.T. and XU S.

Nicotiana attenuata Data Hub (Na DH): an integrative platform for exploring genomic, transcriptomic and metabolomic data in wild tobacco

BMC Genomics, 18:79, 2017. | DOI : 10.1186/s12864-016-3465-9

LIU Z., TAVARES R., FORSYTHE E.S., ANDRE F., LUGAN R., JONASSON G., BOUTET-MERCEY S., TOHGE T., BEILSTEIN M.A., WERCK D. and RENAULT H.

Evolutionary interplay between sister cytochrome P450 genes shapes plasticity in plant metabolism

Nature Communications, 7:13026, 2016. | DOI : 10.1038/ncomms13026

SIBOUT R., LE BRIS P., LEGEE F., CEZARD L., RENAULT H. and LAPIERRE C.

Structural redesigning Arabidopsis lignins into alkali-soluble lignins through the expression of p-coumaroyl-CoA:monolignol transferase PMT

Plant Physiology, 170(3):1358-1366, 2016. | DOI : 10.1104/pp.15.01877

HEITZ T., SMIRNOVA E., WIDEMANN E., AUBERT Y., PINOT F. and MENARD R.

The rise and fall of Jasmonate Biological activities

Sub-cellular biochemistry, 86:405-26, 2016. | DOI : 10.1007/978-3-319-25979-6_16

LI D., HEILING S., BALDWIN I.T. and GAQUEREL E.

Illuminating a plant’s tissue-specific metabolic diversity using computational metabolomics and information theory

Proceedings of the National Academy of Sciences of the United States of America, 113(47):E7610-E7618, 2016. | DOI : 10.1073/pnas.1610218113

HEILING S., KHANAL S., BARSCH A., ZUREK G., BALDWIN I.T. and GAQUEREL E.

Using the knowns to discover the unknowns: MS‐based dereplication uncovers structural diversity in 17‐hydroxygeranyllinalool diterpene glycoside production in the Solanaceae

Plant Journal, 85:561-577, 2016. | DOI : 10.1111/tpj.13119

LI D., BALDWIN I.T. and GAQUEREL E.

Beyond the canon: within-plant and population-level heterogeneity in jasmonate signaling engaged by plant-insect interactions

Plants, 5(1):14, 2016. | DOI : 10.3390/plants5010014

WIDEMANN E., SMIRNOVA E., AUBERT Y., MIESCH L. and HEITZ T.

Dynamics of Jasmonate metabolism upon flowering and accross leaf stress responses in Arabidopsis thaliana

Plants, 5(1):doi : 10.3390/plants5010004, 2016. | DOI : 10.3390/plants5010004

BOACHON B., JUNKER R.R., MIESCH L., BASSARD J.E., HÖFER R., CAILLIEAUDEAUX R., SEIDEL D.E., LESOT A., HEINRICH C., GINGLINGER J.F., ALLOUCHE L., VINCENT B., WAHYUNI D.S.C., PAETZ C., BERAN F., MIESCH M., SCHNEIDER B., LEISS K. and WERCK D.

CYP76C1 (Cytochrome P450)-mediated linalool metabolism and the formation of volatile and soluble linalool oxides in Arabidopsis flowers: a strategy for defense against floral antagonists

Plant Cell, 27:2972-2990, 2015. | DOI : 10.1105/tpc.15.00399

LIU Z., BOACHON B., LUGAN R., TAVARES R., ERHARDT M., MUTTERER J., DEMAIS V., PATEYRON S., BRUNAUD V., OHNISHI T., PENCIK A., ACHARD P., GONG F., HEDDEN P., WERCK D. and RENAULT H.

A conserved cytochrome P450 evolved in seed plants regulates flower maturation

Molecular Plant, 8:1751-1765, 2015. | DOI : 10.1016/j.molp.2015.09.002

AUBERT Y., WIDEMANN E., MIESCH L., PINOT F. and HEITZ T.

CYP94-mediated jasmonoyl-isoleucine hormone oxidation shapes jasmonate profiles and attenuates defence responses to Botrytis cinerea infection

Journal of Experimental Botany, 66(13):3879-3892, 2015. | DOI : 10.1093/jxb/erv190

WIDEMANN E., GRAUSEM B., RENAULT H., PINEAU E., HEINRICH C., LUGAN R., ULLMANN P., MIESCH L., AUBERT Y., MIESCH M., HEITZ T. and PINOT F.

Sequential oxidation of Jasmonoyl-Phenylalanine and Jasmonoyl-Isoleucine by multiple cytochrome P450 of the CYP94 family through newly identified aldehyde intermediates

Phytochemistry, 117:388-399, 2015. | DOI : 10.1016/j.phytochem.2015.06.027

LI D., BALDWIN I.T. and GAQUEREL E.

Navigating natural variation in herbivory-induced secondary metabolism in coyote tobacco populations using MS/MS structural analysis

Proceedings of the National Academy of Sciences of the United States of America, 112(30):E4147-55, 2015. | DOI : 10.1073/pnas.1503106112

RENAULT H., BASSARD J.E., HAMBERGER B. and WERCK D.

Cytochrome P450-mediated metabolic engineering: current progress and future challenges.

Current Opinion in Plant Biology, 19:27-34, 2014. | DOI : 10.1016/j.pbi.2014.03.004

HÖFER R., BOACHON B., RENAULT H., GAVIRA C., MIESCH L., IGLESIAS J., GINGLINGER J.F., ALLOUCHE L., MIESCH M., GREC S., LARBAT R. and WERCK D.

Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides.

Plant Physiology, 166(3):1149-61, 2014. | DOI : 10.1104/pp.114.244814

STITZ M., HARTL M., BALDWIN I.T. and GAQUEREL E.

Jasmonoyl-l-isoleucine coordinates metabolic networks required for anthesis and floral attractant emission in wild tobacco (Nicotiana attenuata)

Plant Cell, , 2014.

GAQUEREL E., GULATI J. and BALDWIN I.T.

Revealing insect herbivory‐induced phenolamide metabolism: from single genes to metabolic network plasticity analysis

Plant Journal, , 2014.

WALTER W., STRIBERNY B., GAQUEREL E., BALDWIN I.T., KIM S.G. and HEILAND I.

Improving the accuracy of expression data analysis in time course experiments using resampling

BMC Bioinformatics, , 2014.

RENAULT H., EL AMRANI A., BERGER A., MOUILLE G., SOUBIGOU-TACONNAT L., BOUCHEREAU A. and DELEU C.

( gamma )-Aminobutyric acid transaminase deficiency impairs central carbon metabolism and leads to cell wall defects during salt stress in Arabidopsis roots.

Plant Cell and Environment, 36:1009-1018, 2013. | DOI : 10.1111/pce.12033

RENAULT H.

Fiat Lux! Phylogeny and Bioinformatics shed light on GABA functions in plants.

Plant Signaling and Behavior, 8(6):e24274, 2013. | DOI : 10.4161/psb.24274

WOLDEMARIAM M., TRUNONG DINH S., OH Y., GAQUEREL E., BALDWIN I.T. and GALIS I.

NaMYC2 transcription factor regulates a subset of plant defense responses in Nicotiana attenuata

BMC Plant Biology, , 2013.

BASSARD J.E., RICHERT L., GEERINCK J., RENAULT H., DUVAL F., ULLMANN P., SCHMITT M., MEYER E.H., MUTTERER J., BOERJAN A., DE JAEGER G., MÉLY Y., GOOSSENS A. and WERCK D.

Protein-Protein and Protein–Membrane Associations in the Lignin Pathway

Plant Cell, 24:4465-4482, 2012. | DOI : 10.1105/tpc.112.102566

RENAULT H., EL AMRANI A., PALANIVELU R., UPDEGRAFF E., YU A., RENOU J., PREUSS D., BOUCHEREAU A. and DELEU C.

GABA accumulation causes cell elongation defects and a decrease in expression of genes encoding secreted and cell wall-related proteins in Arabidopsis thaliana

Plant and Cell Physiology, 52(5):894-908, 2011. | DOI : 10.1093/pcp/pcr041

RENAULT H., ROUSSEL V., EL AMRANI A., ARZEL M., RENAULT D. and DELEU C.

The Arabidopsis pop2-1 mutant reveals the involvement of GABA transaminase in salt stress tolerance

BMC Plant Biology, 10:20, 2010. | DOI : 10.1186/1471-2229-10-20

LEBLANC A., RENAULT H., LECOURT J., ETIENNE P., DELEU C. and LE DEUNFF E.

Elongation changes of exploratory and root hair systems induced by aminocyclopropane carboxylic acid and aminoethoxyvinylglycine affect nitrate uptake and BnNrt2.1 and BnNrt1.1 transporter gene expression in oilseed rape

Plant Physiology, 146(4):1928-1940, 2008. | DOI : 10.1104/pp.107.109363